I145
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I145
Sigma
I-AB-MECA
solid
| Synonym: | 3-Iodo-4-aminobenzyl-5′-N-methylcarboxamidoadenosine, 1-[6-[[(4-Amino-3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β- |
| CAS Number: | 152918-27-9 |
| Linear Formula: | C18H20IN7O4 |
| Molecular Weight: | 525.30 |
| MDL number: | MFCD00671784 |
| PubChem Substance ID: | 24895933 |
Description
| Legal Information | Sold under license from the National Institutes of Health. |
| Biochem/physiol Actions | Reference standard for radioiodinated I-AB-MECA, a widely used, high affinity radioligand for the A3 adenosine receptor. |
Properties
| form | solid |
| color | off-white |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL |
| DMSO: 10 mg/mL | |
| 0.1 M NaOH: 2 mg/mL | |
| 0.1 M HCl: 7 mg/mL | |
| H2O: insoluble | |
| Gene Information | human ... ADORA3(140) |
| rat ... Adora1(29290), Adora2a(25369), Adora3(25370) | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Von Lubitz, et al., The effects of adenosine A3 receptor stimulation on seizures in mice. Eur. J. Pharmacol. 275, 23-29, (1995) Abstract |
| Olah, et al., 125I-4-Aminobenzyl-5′-N-methyl-carboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor. Mol. Pharmacol. 45, 978-982, (1994) Abstract | |
| Jacobson, et al., A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett. 336, 57-60, (1993) Abstract |
